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CD40, èëè TNFRSF5 (àíãë. tumor necrosis factor receptor superfamily member 5) — êîñòèìóëèðóþùèé áåëîê àíòèãåíïðåäñòàâëÿþùèõ êëåòîê, ðåöåïòîð èç íàäñåìåéñòâà ðåöåïòîðà ôàêòîðîâ íåêðîçà îïóõîëè. Ïðîäóêò ãåíà ÷åëîâåêà CD40.
Ñîäåðæàíèå
Ôóíêöèè
CD40 ÿâëÿåòñÿ ðåöåïòîðîì CD154 (TNFSF5), ðàñïîëîæåííîãî íà Ò-õåëïåðàõ. Ðåöåïòîð ó÷àñòâóåò â øèðîêîì ñïåêòðå èììóííûõ è âîñïàëèòåëüíûõ ðåàêöèé, âêëþ÷àÿ Ò-ëèìôîöèò-çàâèñèìîå ïåðåêëþ÷åíèå êëàññîâ èììóíîãëîáóëèíîâ, ðàçâèòèå êëåòîê ïàìÿòè è îáðàçîâàíèå ãåðìèíàòèâíûõ öåíòðîâ. Àäàïòåðíûå áåëêè TRAF1, TRAF2, TRAF6 è, âîçìîæíî, TRAF5 âçàèìîäåéñòâóþò ñ ýòèì ðåöåïòîðîì è ñëóæàò ìåäèàòîðàìè â ïåðåíîñå ñèãíàëà. Ýêñïðåññèÿ êàê CD40, òàê è åãî ëèãàíäà CD154, ðåãóëèðóåòñÿ ôàêòîðîì òðàíñêðèïöèè AKNA.[1]
Âçàèìîäåéñòâèÿ
CD40 âçàèìîäåéñòâóåò ñ TRAF2,[2][3][4] TRAF3,[3][5][6][7] TRAF6,[3][7] TRAF5[3][8] è TTRAP.[9]
Ñì. òàêæå
Ïðèìå÷àíèÿ
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