Ìåíþ
Ãëàâíàÿ
Ñëó÷àéíàÿ ñòàòüÿ
Íàñòðîéêè
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ßäåðíûé ôàêòîð ãåïàòîöèòîâ 4-àëüôà, â ìåæäóíàðîäíîé íîìåíêëàòóðå èçâåñòíûé êàê NR2A1 — ÿäåðíûé ðåöåïòîð, ó ÷åëîâåêà êîäèðóþùèéñÿ ãåíîì HNF4A.
Ñîäåðæàíèå
Ôóíêöèè
NHF4A — ÿäåðíûé ôàêòîð òðàíñêðèïöèè, â âèäå ãîìîäèìåðà ñâÿçûâàþùèéñÿ ñ ÄÍÊ. Äàííûé áåëîê êîíòðîëèðóåò ýêñïðåññèþ íåñêîëüêèõ ãåíîâ, â òîì ÷èñëå ÿäåðíîãî ôàêòîðà ãåïàòîöèòîâ 1-àëüôà (òðàíñêðèïöèîííîãî ôàêòîðà, ðåãóëèðóþùåãî ýêñïðåññèþ íåñêîëüêèõ ãåíîâ ïå÷åíè). Ãåí NHF4A èãðàåò âàæíóþ ðîëü â ðàçâèòèè ïå÷åíè è ïî÷åê.  ðåçóëüòàòå àëüòåðíàòèâíîãî ñïëàéñèíãà îáðàçóåòñÿ íåñêîëüêî âàðèàíòîâ òðàíñêðèïòîâ äàííîãî ãåíà, êîäèðóþùèõ íåñêîëüêî èçîôîðì áåëêà, ñîîòâåòñòâåííî.
Êëèíè÷åñêîå çíà÷åíèå
Ìóòàöèè â ãåíå NHF4A ÿâëÿþòñÿ ïðè÷èíîé ñàõàðíîãî äèàáåòà âçðîñëîãî òèïà ó ìîëîäûõ (MODY-äèàáåòà) è hnf4a-îïîñðåäîâàííîãî ãèïåðèíñóëèíèçìà[àíãë.].
Àëêàëîèä áåðáåðèí ïîâûøàåò ýêñïðåññèþ ãåíà HNF4A.
Âçàèìîäåéñòâèå ãåíà
ßäåðíûé ôàêòîð ãåïàòîöèòîâ 4-àëüôà âçàèìîäåéñòâóåò ñî ñëåäóþùèìè áèîìîëåêóëàìè:
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