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Ãëàâíàÿ
Ñëó÷àéíàÿ ñòàòüÿ
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Èíîçèí-5'-ìîíîôîñôàòäåãèäðîãåíàçà 1 , òàêæå èçâåñòíàÿ êàê IMP äåãèäðîãåíàçà 1 — ôåðìåíò, êîòîðûé ó ÷åëîâåêà êîäèðóåòñÿ ãåíîì IMPDH1. [1] [2]
Ñîäåðæàíèå
Ôóíêöèÿ
Èíîçèí-5'-ìîíîôîñôàòäåãèäðîãåíàçà 1 ïðåäñòàâëÿåò ñîáîé ãîìîòåòðàìåð, êîòîðûé ðåãóëèðóåò ðîñò êëåòîê. IMPDH1 — ýòî ôåðìåíò, êîòîðûé êàòàëèçèðóåò ñèíòåç êñàíòèíìîíîôîñôàòà (XMP) èç èíîçèí-5'-ìîíîôîñôàòà (IMP). Ýòîò ïðîöåññ îãðàíè÷èâàåò ñêîðîñòü ñèíòåçà íóêëåîòèäîâ ãóàíèíà de novo[1].
Êëèíè÷åñêîå çíà÷åíèå
Äåôåêòû â ãåíå IMPDH1 ÿâëÿþòñÿ ïðè÷èíîé ïèãìåíòíîãî ðåòèíèòà òèïà 10[1][3][4].
Ïðèìå÷àíèÿ
- 1 2 3 Entrez Gene: IMP (inosine monophosphate) dehydrogenase 1 .
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