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Áåëîê ìèòîòè÷åñêîé êîíòðîëüíîé òî÷êè ñáîðêè âåðåòåíà äåëåíèÿ MAD2B — áåëîê, êîäèðóåìûé ó ÷åëîâåêà ãåíîì MAD2L2 [1][2].
Ñîäåðæàíèå
Ôóíêöèÿ
MAD2L2 ÿâëÿåòñÿ êîìïîíåíòîì ìèòîòè÷åñêîé êîíòðîëüíîé òî÷êè ñáîðêè âåðåòåíà äåëåíèÿ, êîòîðûé ïðåäîòâðàùàåò âîçíèêíîâåíèå àíàôàçû äî òåõ ïîð, ïîêà âñå õðîìîñîìû íå áóäóò ïðàâèëüíî âûðîâíåíû íà ìåòàôàçíîé ïëàñòèíå. MAD2L2 ÿâëÿåòñÿ ãîìîëîãîì MAD2L1[2].
Âçàèìîäåéñòâèÿ
MAD2L2, êàê áûëî âûÿâëåíî, âçàèìîäåéñòâóåò ñ:
Ïðèìå÷àíèÿ
- Cahill D.P., da Costa L.T., Carson-Walter E.B., Kinzler K.W., Vogelstein B., Lengauer C. Characterization of MAD2B and other mitotic spindle checkpoint genes (àíãë.) // Genomics : journal. — Academic Press, 1999. — August (vol. 58, no. 2). — P. 181—187. — doi:10.1006/geno.1999.5831. — PMID 10366450.
- 1 2 Entrez Gene: MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) (íåîïð.). Àðõèâèðîâàíî 5 äåêàáðÿ 2010 ãîäà.
- Nelson K.K., Schlndorff J., Blobel C.P. Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta (àíãë.) // Biochem. J.[àíãë.] : journal. — 1999. — November (vol. 343, no. 3). — P. 673—680. — doi:10.1042/0264-6021:3430673. — PMID 10527948. — PMC 1220601.
- 1 2 Murakumo Y., Roth T., Ishii H., Rasio D., Numata S., Croce C.M., Fishel R. A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2 (àíãë.) // J. Biol. Chem. : journal. — 2000. — February (vol. 275, no. 6). — P. 4391—4397. — doi:10.1074/jbc.275.6.4391. — PMID 10660610.
- 1 2 Murakumo Y., Ogura Y., Ishii H., Numata S., Ichihara M., Croce C.M., Fishel R., Takahashi M. Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7 (àíãë.) // J. Biol. Chem. : journal. — 2001. — September (vol. 276, no. 38). — P. 35644—35651. — doi:10.1074/jbc.M102051200. — PMID 11485998.
Ëèòåðàòóðà- Nelson K.K., Schlndorff J., Blobel C.P. Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta (àíãë.) // Biochem. J.[àíãë.] : journal. — 1999. — Vol. 343, no. 3. — P. 673—680. — doi:10.1042/0264-6021:3430673. — PMID 10527948. — PMC 1220601.
- Murakumo Y., Roth T., Ishii H., Rasio D., Numata S., Croce C.M., Fishel R. A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2 (àíãë.) // J. Biol. Chem. : journal. — 2000. — Vol. 275, no. 6. — P. 4391—4397. — doi:10.1074/jbc.275.6.4391. — PMID 10660610.
- Chan S.H., Hung F.S., Chan D.S., Shaw P.C. Trichosanthin interacts with acidic ribosomal proteins P0 and P1 and mitotic checkpoint protein MAD2B (àíãë.) // Eur. J. Biochem.[àíãë.] : journal. — 2001. — Vol. 268, no. 7. — P. 2107—2112. — doi:10.1046/j.1432-1327.2001.02091.x. — PMID 11277934.
- Chen J., Fang G. MAD2B is an inhibitor of the anaphase-promoting complex (àíãë.) // Genes Dev. : journal. — 2001. — Vol. 15, no. 14. — P. 1765—1770. — doi:10.1101/gad.898701. — PMID 11459826. — PMC 312737.
- Murakumo Y., Ogura Y., Ishii H., Numata S., Ichihara M., Croce C.M., Fishel R., Takahashi M. Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7 (àíãë.) // J. Biol. Chem. : journal. — 2001. — Vol. 276, no. 38. — P. 35644—35651. — doi:10.1074/jbc.M102051200. — PMID 11485998.
- Weterman M.A., van Groningen J.J., Tertoolen L., van Kessel A.G. Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas (àíãë.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 2001. — Vol. 98, no. 24. — P. 13808—13813. — doi:10.1073/pnas.241304198. — PMID 11717438. — PMC 61123.
- Masuda Y., Ohmae M., Masuda K., Kamiya K. Structure and enzymatic properties of a stable complex of the human REV1 and REV7 proteins (àíãë.) // J. Biol. Chem. : journal. — 2003. — Vol. 278, no. 14. — P. 12356—12360. — doi:10.1074/jbc.M211765200. — PMID 12529368.
- Ying B., Wold W.S. Adenovirus ADP protein (E3-11.6K), which is required for efficient cell lysis and virus release, interacts with human MAD2B (àíãë.) // Virology : journal. — 2003. — Vol. 313, no. 1. — P. 224—234. — doi:10.1016/S0042-6822(03)00287-3. — PMID 12951035.
- Lehner B., Semple J.I., Brown S.E., Counsell D., Campbell R.D., Sanderson C.M. Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region (àíãë.) // Genomics : journal. — Academic Press, 2004. — Vol. 83, no. 1. — P. 153—167. — doi:10.1016/S0888-7543(03)00235-0. — PMID 14667819.
- Ohashi E., Murakumo Y., Kanjo N., Akagi J., Masutani C., Hanaoka F., Ohmori H. Interaction of hREV1 with three human Y-family DNA polymerases (àíãë.) // Genes Cells[àíãë.] : journal. — 2004. — Vol. 9, no. 6. — P. 523—531. — doi:10.1111/j.1356-9597.2004.00747.x. — PMID 15189446.
- Rual J.F., Venkatesan K., Hao T., Hirozane-Kishikawa T., Dricot A., Li N., Berriz G.F., Gibbons F.D., Dreze M., Ayivi-Guedehoussou N., Klitgord N., Simon C., Boxem M., Milstein S., Rosenberg J., Goldberg D.S., Zhang L.V., Wong S.L., Franklin G., Li S., Albala J.S., Lim J., Fraughton C., Llamosas E., Cevik S., Bex C., Lamesch P., Sikorski R.S., Vandenhaute J., Zoghbi H.Y., Smolyar A., Bosak S., Sequerra R., Doucette-Stamm L., Cusick M.E., Hill D.E., Roth F.P., Vidal M. Towards a proteome-scale map of the human protein-protein interaction network (àíãë.) // Nature : journal. — 2005. — Vol. 437, no. 7062. — P. 1173—1178. — doi:10.1038/nature04209. — PMID 16189514.
- Rimkus C., Friederichs J., Rosenberg R., Holzmann B., Siewert J.R., Janssen K.P. Expression of the mitotic checkpoint gene MAD2L2 has prognostic significance in colon cancer (àíãë.) // Int. J. Cancer[àíãë.] : journal. — 2007. — Vol. 120, no. 1. — P. 207—211. — doi:10.1002/ijc.22155. — PMID 17044027.
- Zhang L., Yang S.H., Sharrocks A.D. Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1 (àíãë.) // Mol. Cell. Biol. : journal. — 2007. — Vol. 27, no. 8. — P. 2861—2869. — doi:10.1128/MCB.02276-06. — PMID 17296730. — PMC 1899940.
- Pinto M., Soares M.J., Cerveira N., Henrique R., Ribeiro F.R., Oliveira J., Jernimo C., Teixeira M.R. Expression changes of the MAD mitotic checkpoint gene family in renal cell carcinomas characterized by numerical chromosome changes (àíãë.) // Virchows Arch.[àíãë.] : journal. — 2007. — Vol. 450, no. 4. — P. 379—385. — doi:10.1007/s00428-007-0386-7. — PMID 17333263.
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