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Ñóáúåäèíèöà RPB3 ÄÍÊ-óïðàâëÿåìîé ÐÍÊ-ïîëèìåðàçû II — ôåðìåíò, êîäèðóåìûé ó ÷åëîâåêà ãåíîì POLR2C .[1]
Ñîäåðæàíèå
Ôóíêöèÿ
Ýòîò ãåí êîäèðóåò òðåòüþ ïî âåëè÷èíå ñóáúåäèíèöó ÐÍÊ-ïîëèìåðàçû II, ïîëèìåðàçû, îòâåòñòâåííîé çà ñèíòåç ìåññåíäæåðà ÐÍÊ ó ýóêàðèîò. Ïðîäóêò ýòîãî ãåíà ñîäåðæèò áîãàòóþ öèñòåèíîì îáëàñòü è ñóùåñòâóåò â âèäå ãåòåðîäèìåðà ñ äðóãîé ïîëèìåðàçíîé ñóáúåäèíèöåé, POLR2J. Ýòè äâå ñóáúåäèíèöû îáðàçóþò îñíîâíîé áëîê ïîëèìåðàçû. Ïñåâäîãåí áûë èäåíòèôèöèðîâàí íà õðîìîñîìå 21.[2]
Âçàèìîäåéñòâèÿ
POLR2C, êàê áûëî âûÿâëåíî, âçàèìîäåéñòâóþò ñ:
- ATF4,[3]
- CCHCR1,[4]
- Myogenin,[5]
- POLR2A,[6]
- POLR2B,[6]
- POLR2E[6]
- POLR2F,[6]
- POLR2G,[6]
- POLR2H,[6]
- POLR2J,[6][5]
- POLR2K,[6]
- POLR2L,[6]
- TAF15.[7]
Ïðèìå÷àíèÿ
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- Entrez Gene: POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa (íåîïð.).
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