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Ñóáúåäèíèöà RPABC5 ÄÍÊ-óïðàâëÿåìûõ ÐÍÊ-ïîëèìåðàç I, II è III — áåëîê, êîäèðóåìûé ó ÷åëîâåêà ãåíîì POLR2L .[1]
Ñîäåðæàíèå
Ôóíêöèÿ
Ýòîò ãåí êîäèðóåò ñóáúåäèíèöó ÐÍÊ-ïîëèìåðàçû II, ïîëèìåðàçû, îòâåòñòâåííîé çà ñèíòåç ìåññåíäæåðà ÐÍÊ ó ýóêàðèîò. Ïðîäóêò ýòîãî ãåíà ñîäåðæèò ÷åòûðå êîíñåðâàòèâíûõ öèñòåèíà, õàðàêòåðíûõ äëÿ àòèïè÷íîãî öèíêîñâÿçûâàþùåãî äîìåíà. Êàê è å¸ êîëëåãà â äðîææàõ, ýòà ñóáúåäèíèöà ìîæåò òàêæå ó÷àñòâîâàòü è â äâóõ äðóãèõ ÄÍÊ-óïðàâëÿåìûõ ÐÍÊ-ïîëèìåðàçàõ.[2]
Âçàèìîäåéñòâèÿ
POLR2L, êàê áûëî âûÿâëåíî, âçàèìîäåéñòâóåò ñ POLR2C,[3] POLR2A,[3] POLR2B[3] è POLR2E.[3]
Ïðèìå÷àíèÿ
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- Entrez Gene: POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa (íåîïð.).
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