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Ãëàâíàÿ
Ñëó÷àéíàÿ ñòàòüÿ
Íàñòðîéêè
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Ðåãóëÿòîðíûé ôàêòîð èíòåðôåðîíà 3, èçâåñòíûé òàêæå êàê IRF3 — îäèí èç ðåãóëÿòîðíûõ ôàêòîðîâ èíòåðôåðîíîâ.[1]
Ñîäåðæàíèå
Ôóíêöèÿ
IRF3 ÿâëÿåòñÿ ÷ëåíîì ñåìåéñòâà ðåãóëÿòîðíûõ ôàêòîðîâ òðàíñêðèïöèè (IRF) èíòåðôåðîíîâ.[1] IRF3 áûë ïåðâîíà÷àëüíî îáíàðóæåí â ãîìîëîãàõ IRF1 è IRF2. IRF3 áûë äîïîëíèòåëüíî îõàðàêòåðèçîâàí è, êàê áûëî âûÿâëåíî, ñîäåðæèò íåñêîëüêî ôóíêöèîíàëüíûõ äîìåíîâ, â òîì ÷èñëå äîìåí ÿäåðíîãî ýêñïîðòà ñèãíàëà, ÄÍÊ-ñâÿçûâàþùèé äîìåí, àññîöèàöèþ ñ Ñ-êîíöåâîé îáëàñòüþ ÌÀÔ è íåñêîëüêî ðåãóëÿòîðíûõ ôîñôîðèëèðîâàííûõ ñàéòîâ.[2] IRF3 íàõîäèòñÿ â íåàêòèâíîé öèòîïëàçìàòè÷åñêîé ôîðìå, ïðè ñåðèí/ òðåîíèí-ôîñôîðèëèðîâàíèè îáðàçóåò êîìïëåêñ ñ CREBBP[3] Ýòîò êîìïëåêñ òðàíñëîöèðóåòñÿ â ÿäðî è àêòèâèðóåò òðàíñêðèïöèþ èíòåðôåðîíîâ àëüôà è áåòà, à òàêæå äðóãèõ èíòåðôåðîí-èíäóöèðîâàííîé ãåíîâ.[4]
IRF3 èãðàåò âàæíóþ ðîëü â ñèñòåìå âðîæäåííîãî èììóííîãî îòêëèêà íà âèðóñíóþ èíôåêöèþ.[5] Áûëè íàéäåíû àãðåãàòèðîâàííûå MAVS[àíãë.], ÷òîáû àêòèâèðîâàòü äèìåðèçàöèþ IRF3.[6]
Âçàèìîäåéñòâèÿ
IRF3 áûëî ïîêàçàíî, âçàèìîäåéñòâóþò ñ IRF7.[7]
Ñì. òàêæå
Ïðèìå÷àíèÿ
- 1 2 Hiscott J., Pitha P., Genin P., Nguyen H., Heylbroeck C., Mamane Y., Algarte M., Lin R. Triggering the interferon response: the role of IRF-3 transcription factor (àíãë.) // J. Interferon Cytokine Res. : journal. — 1999. — Vol. 19, no. 1. — P. 1—13. — doi:10.1089/107999099314360. — PMID 10048763.
- Lin R., Heylbroeck C., Genin P., Pitha P.M., Hiscott J. Essential Role of Interferon Regulatory Factor 3 in Direct Activation of RANTES Chemokine Transcription (àíãë.) // Mol Cell Biol : journal. — 1999. — February (vol. 19, no. 2). — P. 959—966. — PMID 9891032. — PMC 116027.
- Yoneyama M., Suhara W., Fujita T. Control of IRF-3 activation by phosphorylation (íåîïð.) // J. Interferon Cytokine Res.. — 2002. — Ò. 22, ¹ 1. — Ñ. 73—6. — doi:10.1089/107999002753452674. — PMID 11846977.
- Entrez Gene: IRF3 interferon regulatory factor 3 (íåîïð.).
- Collins S.E., Noyce R.S., Mossman K.L. Innate Cellular Response to Virus Particle Entry Requires IRF3 but Not Virus Replication (àíãë.) // J Virol[àíãë.] : journal. — 2004. — February (vol. 78, no. 4). — P. 1706—1717. — doi:10.1128/JVI.78.4.1706-1717.2004. — PMID 14747536. — PMC 369475.
- Hou F., Sun L., Zheng H., Skaug B., Jiang Q.X., Chen Z.J. MAVS Forms Functional Prion-Like Aggregates To Activate and Propagate Antiviral Innate Immune Response (àíãë.) // Cell : journal. — Cell Press, 2011. — 5 August (vol. 146, no. 3). — P. 448—461. — doi:10.1016/j.cell.2011.06.041. — PMID 21782231. — PMC 3179916.
- Au W.C., Yeow W.S., Pitha P.M. Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3 (àíãë.) // Virology : journal. — 2001. — February (vol. 280, no. 2). — P. 273—282. — doi:10.1006/viro.2000.0782. — PMID 11162841.
Ëèòåðàòóðà- Pitha P.M., Au W.C., Lowther W., Juang Y.T., Schafer S.L., Burysek L., Hiscott J., Moore P.A. Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth (àíãë.) // Biochimie[àíãë.] : journal. — 1999. — Vol. 80, no. 8—9. — P. 651—658. — doi:10.1016/S0300-9084(99)80018-2. — PMID 9865487.
- Yoneyama M., Suhara W., Fujita T. Control of IRF-3 activation by phosphorylation (íåîïð.) // J. Interferon Cytokine Res.. — 2002. — Ò. 22, ¹ 1. — Ñ. 73—6. — doi:10.1089/107999002753452674. — PMID 11846977.
- Au W.C., Moore P.A., Lowther W., Juang Y.T., Pitha P.M. Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes (àíãë.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1996. — Vol. 92, no. 25. — P. 11657—11661. — doi:10.1073/pnas.92.25.11657. — PMID 8524823. — PMC 40461.
- Yoneyama M., Suhara W., Fukuhara Y., Fukuda M., Nishida E., Fujita T. Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300 (àíãë.) // EMBO J. : journal. — 1998. — Vol. 17, no. 4. — P. 1087—1095. — doi:10.1093/emboj/17.4.1087. — PMID 9463386. — PMC 1170457.
- Weaver B.K., Kumar K.P., Reich N.C. Interferon Regulatory Factor 3 and CREB-Binding Protein/p300 Are Subunits of Double-Stranded RNA-Activated Transcription Factor DRAF1 (àíãë.) // Mol. Cell. Biol. : journal. — 1998. — Vol. 18, no. 3. — P. 1359—1368. — PMID 9488451. — PMC 108849.
- Lin R., Heylbroeck C., Pitha P.M., Hiscott J. Virus-Dependent Phosphorylation of the IRF-3 Transcription Factor Regulates Nuclear Translocation, Transactivation Potential, and Proteasome-Mediated Degradation (àíãë.) // Mol. Cell. Biol. : journal. — 1998. — Vol. 18, no. 5. — P. 2986—2996. — PMID 9566918. — PMC 110678.
- Ronco L.V., Karpova A.Y., Vidal M., Howley P.M. Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity (àíãë.) // Genes Dev. : journal. — 1998. — Vol. 12, no. 13. — P. 2061—2072. — doi:10.1101/gad.12.13.2061. — PMID 9649509. — PMC 316980.
- Bellingham J., Gregory-Evans K., Gregory-Evans C.Y. Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker (àíãë.) // Annals of Human Genetics[àíãë.] : journal. — 1999. — Vol. 62, no. Pt 3. — P. 231—234. — doi:10.1046/j.1469-1809.1998.6230231.x. — PMID 9803267.
- Lowther W.J., Moore P.A., Carter K.C., Pitha P.M. Cloning and functional analysis of the human IRF-3 promoter (àíãë.) // DNA Cell Biol.[àíãë.] : journal. — 1999. — Vol. 18, no. 9. — P. 685—692. — doi:10.1089/104454999314962. — PMID 10492399.
- Kim T., Kim T.Y., Song Y.H., Min I.M., Yim J., Kim T.K. Activation of interferon regulatory factor 3 in response to DNA-damaging agents (àíãë.) // J. Biol. Chem. : journal. — 1999. — Vol. 274, no. 43. — P. 30686—30689. — doi:10.1074/jbc.274.43.30686. — PMID 10521456.
- Kumar K.P., McBride K.M., Weaver B.K., Dingwall C., Reich N.C. Regulated Nuclear-Cytoplasmic Localization of Interferon Regulatory Factor 3, a Subunit of Double-Stranded RNA-Activated Factor 1 (àíãë.) // Mol. Cell. Biol. : journal. — 2000. — Vol. 20, no. 11. — P. 4159—4168. — doi:10.1128/MCB.20.11.4159-4168.2000. — PMID 10805757. — PMC 85785.
- Suhara W., Yoneyama M., Iwamura T., Yoshimura S., Tamura K., Namiki H., Aimoto S., Fujita T. Analyses of virus-induced homomeric and heteromeric protein associations between IRF-3 and coactivator CBP/p300 (àíãë.) // J. Biochem.[àíãë.] : journal. — 2000. — Vol. 128, no. 2. — P. 301—307. — doi:10.1093/oxfordjournals.jbchem.a022753. — PMID 10920266.
- Servant M.J., ten Oever B., LePage C., Conti L., Gessani S., Julkunen I., Lin R., Hiscott J. Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3 (àíãë.) // J. Biol. Chem. : journal. — 2001. — Vol. 276, no. 1. — P. 355—363. — doi:10.1074/jbc.M007790200. — PMID 11035028.
- Smith E.J., Mari I., Prakash A., Garca-Sastre A., Levy D.E. IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein (àíãë.) // J. Biol. Chem. : journal. — 2001. — Vol. 276, no. 12. — P. 8951—8957. — doi:10.1074/jbc.M008717200. — PMID 11124948.
- Au W.C., Yeow W.S., Pitha P.M. Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3 (àíãë.) // Virology : journal. — 2001. — Vol. 280, no. 2. — P. 273—282. — doi:10.1006/viro.2000.0782. — PMID 11162841.
- Barnes B.J., Moore P.A., Pitha P.M. Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes (àíãë.) // J. Biol. Chem. : journal. — 2001. — Vol. 276, no. 26. — P. 23382—23390. — doi:10.1074/jbc.M101216200. — PMID 11303025.
- Mach C.M., Hargrove B.W., Kunkel G.R. The Small RNA gene activator protein, SphI postoctamer homology-binding factor/selenocysteine tRNA gene transcription activating factor, stimulates transcription of the human interferon regulatory factor-3 gene (àíãë.) // J. Biol. Chem. : journal. — 2002. — Vol. 277, no. 7. — P. 4853—4858. — doi:10.1074/jbc.M108308200. — PMID 11724783.
- Morin P., Bragana J., Bandu M.T., Lin R., Hiscott J., Doly J., Civas A. Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription (àíãë.) // J. Mol. Biol.[àíãë.] : journal. — 2002. — Vol. 316, no. 5. — P. 1009—1022. — doi:10.1006/jmbi.2001.5401. — PMID 11884139.
- Dang O., Navarro L., Anderson K., David M. Cutting edge: anthrax lethal toxin inhibits activation of IFN-regulatory factor 3 by lipopolysaccharide (àíãë.) // J. Immunology : journal. — 2004. — Vol. 172, no. 2. — P. 747—751. — doi:10.4049/jimmunol.172.2.747. — PMID 14707042.
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