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Ðåãóëÿòîðíûé ôàêòîð èíòåðôåðîíà 2 — áåëîê, êîòîðûé ó ÷åëîâåêà êîäèðóåòñÿ ãåíîì IRF2[1].
Ñîäåðæàíèå
Ôóíêöèÿ
IRF2 êîäèðóåò ðåãóëÿòîðíûé ôàêòîð èíòåðôåðîíà 2, ÷ëåíà ñåìåéñòâà ðåãóëÿòîðíûõ ôàêòîðîâ òðàíñêðèïöèè èíòåðôåðîíà (IRF). IRF2 êîíêóðåíòíî ïîäàâëÿåò IRF1-îïîñðåäîâàííóþ àêòèâàöèþ òðàíñêðèïöèè èíòåðôåðîíîâ àëüôà è áåòà, è, âåðîÿòíî, äðóãèõ ãåíîâ, êîòîðûå èñïîëüçóþò IRF1 äëÿ àêòèâàöèè òðàíñêðèïöèè. Òåì íå ìåíåå, IRF2 òàêæå ôóíêöèîíèðóåò êàê àêòèâàòîð òðàíñêðèïöèè â ãèñòîíå Í4[àíãë.][2].
Âçàèìîäåéñòâèÿ
IRF2, êàê áûëî âûÿâëåíî, âçàèìîäåéñòâóåò ñ BRD7[3], EP300[4] è PCAF[4][5].
Ñì. òàêæå
Ïðèìå÷àíèÿ
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